TKIM

Modify Date: 2024-07-18 08:13:40

TKIM Structure
TKIM structure
Common Name TKIM
CAS Number 326921-25-9 Molecular Weight 371.84
Density N/A Boiling Point N/A
Molecular Formula C18H14ClN3O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TKIM


TKIM is a TREK-1 channel inhibitor with an IC50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1[1].

 Names

Name N'-(4-chlorobenzoyl)-2-(quinolin-2-ylsulfanyl)acetohydrazide

 TKIM Biological Activity

Description TKIM is a TREK-1 channel inhibitor with an IC50 of 2.96 μM. TKIM binds to the pocket of the intermediate (IM) state of TREK-1[1].
Related Catalog
References

[1]. Yuqin Ma, et al. Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating. J Med Chem. 2020 Oct 8;63(19):10972-10983.  

 Chemical & Physical Properties

Molecular Formula C18H14ClN3O2S
Molecular Weight 371.84
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