cis,trans-Germacrone

Modify Date: 2024-01-14 13:19:49

cis,trans-Germacrone Structure
cis,trans-Germacrone structure
Common Name cis,trans-Germacrone
CAS Number 32663-51-7 Molecular Weight 218.33500
Density N/A Boiling Point N/A
Molecular Formula C15H22O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of cis,trans-Germacrone


cis,trans-Germacrone is a isomer of Germacrone (HY-N0440). Germacrone exhibits a wide range of antitumor, antioxidant and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters the Akt/MDM2/p53. Germacrone also arrests cell cycle at G1/S phase[1].

 Names

Name 3,7-dimethyl-10-propan-2-ylidenecyclodeca-3,7-dien-1-one
Synonym More Synonyms

 cis,trans-Germacrone Biological Activity

Description cis,trans-Germacrone is a isomer of Germacrone (HY-N0440). Germacrone exhibits a wide range of antitumor, antioxidant and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters the Akt/MDM2/p53. Germacrone also arrests cell cycle at G1/S phase[1].
Related Catalog
References

[1]. Zhao Y, et al. Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway. Mol Med Rep. 2021 Jun;23(6):452.  

 Chemical & Physical Properties

Molecular Formula C15H22O
Molecular Weight 218.33500
Exact Mass 218.16700
PSA 17.07000
LogP 4.35850

 Synthetic Route

~%

cis,trans-Germacrone Structure

cis,trans-Germacrone

CAS#:32663-51-7

Literature: Takeda,K. et al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 2212 - 2220

~3%

cis,trans-Germacrone Structure

cis,trans-Germacrone

CAS#:32663-51-7

Detail
Literature: Orahovats, A. S.; Bozhkova, N. V.; Hilpert, H. Tetrahedron Letters, 1983 , vol. 24, # 9 p. 947 - 950

 Precursor & DownStream

Precursor  1

DownStream  0

 Synonyms

cis,trans-Germacron