32663-51-7

32663-51-7 structure

Name: cis,trans-Germacrone
Chemical Name: 3,7-dimethyl-10-propan-2-ylidenecyclodeca-3,7-dien-1-one
CAS Number: 32663-51-7
Molecular Formula: C₁₅H₂₂O
Molecular Weight: 218.33500
Catalog: Signaling Pathways Apoptosis MDM-2/p53
Create Date: 2017-01-23 21:14:27
Modify Date: 2024-01-14 13:19:49
cis,trans-Germacrone is a isomer of Germacrone (HY-N0440). Germacrone exhibits a wide range of antitumor, antioxidant and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters the Akt/MDM2/p53. Germacrone also arrests cell cycle at G1/S phase[1].

Name	3,7-dimethyl-10-propan-2-ylidenecyclodeca-3,7-dien-1-one
Synonyms	cis,trans-Germacron

Description	cis,trans-Germacrone is a isomer of Germacrone (HY-N0440). Germacrone exhibits a wide range of antitumor, antioxidant and anti-inflammatory effects. Germacrone inhibits lung cancer cell proliferation and alters the Akt/MDM2/p53. Germacrone also arrests cell cycle at G1/S phase[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53 Signaling Pathways >> PI3K/Akt/mTOR >> Akt
References	[1]. Zhao Y, et al. Germacrone induces lung cancer cell apoptosis and cell cycle arrest via the Akt/MDM2/p53 signaling pathway. Mol Med Rep. 2021 Jun;23(6):452.

Molecular Formula	C₁₅H₂₂O
Molecular Weight	218.33500
Exact Mass	218.16700
PSA	17.07000
LogP	4.35850

6902-91-6

32663-51-7

Literature: Takeda,K. et al. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1973 , p. 2212 - 2220

116713-46-3

~3%

32663-51-7

25644-64-8

Detail

Literature: Orahovats, A. S.; Bozhkova, N. V.; Hilpert, H. Tetrahedron Letters, 1983 , vol. 24, # 9 p. 947 - 950

Precursor 1
6902-91-6
DownStream 0

32663-51-7	5259-71-2
100330-26-5	138805-26-2
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28161-63-9	2203-74-9
62255-30-5	303801-38-9