ICA 110381

Modify Date: 2025-08-25 15:59:44

ICA 110381 Structure
ICA 110381 structure
 Common Name ICA 110381
CAS Number 325457-99-6 Molecular Weight 267.11
Density N/A Boiling Point N/A
Molecular Formula C12H8Cl2N2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ICA 110381


ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1].

 Names

Name 4-Chloro-N-(6-chloro-3-pyridinyl)benzamide
Synonym More Synonyms

 ICA 110381 Biological Activity

Description ICA 110381 (Compound 16) is a KCNQ2/Q3 potassium channel opener for the treatment of epilepsy. ICA 110381 is a KCNQ2/Q3 agonist (EC50=0.38 μM) as well as KCNQ1 antagonist (IC50=15 μM)[1].
Related Catalog
Target

EC50: 0.38 μM (KCNQ2/Q3 potassium channel)[1] IC50: 15 μM (KCNQ1)[1]

References

[1]. Amato G, et al. N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med Chem Lett. 2011 Mar 31;2(6):481-4.

 Chemical & Physical Properties

Molecular Formula C12H8Cl2N2O
Molecular Weight 267.11
Exact Mass 266.00100
PSA 41.99000
LogP 3.71370

 Synonyms

2-acetamido-6-chloropyridine
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Chemsrc provides ICA 110381(CAS#:325457-99-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of ICA 110381 are included as well.>> amp version: ICA 110381

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