2-(Cyclohexanecarboxamido)acetic acid

Modify Date: 2024-01-14 12:49:46

2-(Cyclohexanecarboxamido)acetic acid Structure
2-(Cyclohexanecarboxamido)acetic acid structure
Common Name 2-(Cyclohexanecarboxamido)acetic acid
CAS Number 32377-88-1 Molecular Weight 185.22000
Density 1.174g/cm3 Boiling Point 434.6ºC at 760mmHg
Molecular Formula C9H15NO3 Melting Point N/A
MSDS N/A Flash Point 216.6ºC

 Use of 2-(Cyclohexanecarboxamido)acetic acid


Hexahydrohippuric acid is a metabolite of Shikimate acid in both liver and kidney, under microbial metabolism effect. Hexahydrohippuric acid is made of cyclohexane carboxylic acid and glycinamide, and shows antibacterial activity[1][2].

 Names

Name 2-(cyclohexanecarbonylamino)acetic acid
Synonym More Synonyms

 2-(Cyclohexanecarboxamido)acetic acid Biological Activity

Description Hexahydrohippuric acid is a metabolite of Shikimate acid in both liver and kidney, under microbial metabolism effect. Hexahydrohippuric acid is made of cyclohexane carboxylic acid and glycinamide, and shows antibacterial activity[1][2].
Related Catalog
References

[1]. Uenishi H, Bacteriostatic or antibacterial agents containing amide of cyclohexanecarboxylic acid with amino acid and phytopathogenic bacteria control agents, food, etc., containing the agents: Japan, JP2015093867[P]. 2015-05-18.

[2]. Brewster D, et al. The metabolism of cyclohexanecarboxylate in the rat. Biochem J. 1977 Jun 15;164(3):595-600.

 Chemical & Physical Properties

Density 1.174g/cm3
Boiling Point 434.6ºC at 760mmHg
Molecular Formula C9H15NO3
Molecular Weight 185.22000
Flash Point 216.6ºC
Exact Mass 185.10500
PSA 66.40000
LogP 1.15840
Index of Refraction 1.503

 Safety Information

HS Code 2924299090

 Synthetic Route

~99%

2-(Cyclohexanecarboxamido)acetic acid Structure

2-(Cyclohexanec...

CAS#:32377-88-1

Literature: Todd, Matthew H.; Ndubaku, Chudi; Bartlett, Paul A. Journal of Organic Chemistry, 2002 , vol. 67, # 12 p. 3985 - 3988

~85%

2-(Cyclohexanecarboxamido)acetic acid Structure

2-(Cyclohexanec...

CAS#:32377-88-1

Literature: Brandt, Gary E. L.; Blagg, Brian S. J. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 10 p. 735 - 740

~%

2-(Cyclohexanecarboxamido)acetic acid Structure

2-(Cyclohexanec...

CAS#:32377-88-1

Literature: Alargov, Dimitar K.; Gugova, Roumyana G.; Denkova, Pavleta S.; Mueller, Gunther; Golovinsky, Evgeny V. Monatshefte fur Chemie, 1999 , vol. 130, # 7 p. 937 - 943

~91%

2-(Cyclohexanecarboxamido)acetic acid Structure

2-(Cyclohexanec...

CAS#:32377-88-1

Literature: Ferreira, Rafaela S.; Simeonov, Anton; Jadhav, Ajit; Eidam, Oliv; Mott, Bryan T.; Keiser, Michael J.; McKerrow, James H.; Maloney, David J.; Irwin, John J.; Shoichet, Brian K. Journal of Medicinal Chemistry, 2010 , vol. 53, # 13 p. 4891 - 4905

~%

2-(Cyclohexanecarboxamido)acetic acid Structure

2-(Cyclohexanec...

CAS#:32377-88-1

Literature: Lang, Lixin; Jagoda, Elaine; Schmall, Bernard; Vuong, Bik-Kee; Adams, H. Richard; Nelson, David L.; Carson, Richard E.; Eckelman, William C. Journal of Medicinal Chemistry, 1999 , vol. 42, # 9 p. 1576 - 1586

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

Cyclohexanoylglycine
Hexahydrohippurate
cyclohexanecarbonylglycine
N-cyclohexanoyl glycine
cyclohexylcarbonylglycine
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