ACS medicinal chemistry letters

Monoenomycin: a simplified trienomycin A analogue that manifests anticancer activity

GEL Brandt, BSJ Blagg

Index: Brandt, Gary E. L.; Blagg, Brian S. J. ACS Medicinal Chemistry Letters, 2011 , vol. 2, # 10 p. 735 - 740

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Citation Number: 6

Abstract

Macrocyclic natural products are a powerful class of leadlike chemical entities. Despite commonly violating Lipinski's “rule of 5”, these compounds often demonstrate superior druglike physicochemical and pharmacokinetic attributes when compared to their acyclic counterparts. However, the elaborate structural architectures of such molecules require rigorous synthetic investigation that complicates analogue development and their ...