2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide

Modify Date: 2025-08-29 08:16:36

2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide structure	Common Name	2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide
	CAS Number	322-35-0	Molecular Weight	257.24300
	Density	1.541 g/cm3	Boiling Point	574.2ºC at 760 mmHg
	Molecular Formula	C₁₀H₁₅N₃O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	301ºC

Use of 2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide

Benserazide is a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the research of melanoma[1].

Name	benserazide
Synonym	More Synonyms

Description	Benserazide is a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the research of melanoma[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Zhou Y, et al. Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment. Int J Cancer. 2020 Jul 1;147(1):139-151.

Density	1.541 g/cm3
Boiling Point	574.2ºC at 760 mmHg
Molecular Formula	C₁₀H₁₅N₃O₅
Molecular Weight	257.24300
Flash Point	301ºC
Exact Mass	257.10100
PSA	148.07000
Index of Refraction	1.678
InChIKey	BNQDCRGUHNALGH-UHFFFAOYSA-N
SMILES	NC(CO)C(=O)NNCc1ccc(O)c(O)c1O

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT9632200

CHEMICAL NAME :: Serine, 2-(2,3,4-trihydroxybenzyl)hyrazide, DL-

CAS REGISTRY NUMBER :: 322-35-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H15-N3-O5

MOLECULAR WEIGHT :: 257.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23400 mg/kg/90D-C

TOXIC EFFECTS :: Behavioral - ataxia Kidney, Ureter, Bladder - other changes in urine composition Musculoskeletal - other changes

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2880 mg/kg

SEX/DURATION :: female 90 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982

Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S26
HS Code	2928000090

HS Code	2928000090
Summary	2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

bensarazide

Benseraszide

Ro 4-4602

Benserazida

DL-Seryltrihydroxybenzylhydrazine

MFCD00242633

2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide

Serazide

Benserazidum

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2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide

Use of 2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide

Names

Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Customs

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.