2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide

Names

[ CAS No. ]:
322-35-0

[ Name ]:
2-Amino-3-hydroxy-2'-(2,3,4-trihydroxybenzyl)propionohydrazide

[Synonym ]:
bensarazide
Benseraszide
Ro 4-4602
Benserazida
DL-Seryltrihydroxybenzylhydrazine
MFCD00242633
2-amino-3-hydroxy-N'-[(2,3,4-trihydroxyphenyl)methyl]propanehydrazide
Serazide
Benserazidum

Biological Activity

[Description]:

Benserazide is a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the research of melanoma[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Zhou Y, et al. Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment. Int J Cancer. 2020 Jul 1;147(1):139-151.

Chemical & Physical Properties

[ Density]:
1.541 g/cm3

[ Boiling Point ]:
574.2ºC at 760 mmHg

[ Molecular Formula ]:
C₁₀H₁₅N₃O₅

[ Molecular Weight ]:
257.24300

[ Flash Point ]:
301ºC

[ Exact Mass ]:
257.10100

[ PSA ]:
148.07000

[ Index of Refraction ]:
1.678

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT9632200

CHEMICAL NAME :: Serine, 2-(2,3,4-trihydroxybenzyl)hyrazide, DL-

CAS REGISTRY NUMBER :: 322-35-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C10-H15-N3-O5

MOLECULAR WEIGHT :: 257.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 23400 mg/kg/90D-C

TOXIC EFFECTS :: Behavioral - ataxia Kidney, Ureter, Bladder - other changes in urine composition Musculoskeletal - other changes

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 2880 mg/kg

SEX/DURATION :: female 90 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Maternal Effects - uterus, cervix, vagina

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 66,201,1982

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ HS Code ]:
2928000090

Customs

[ HS Code ]: 2928000090

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Related Compounds

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