2-Hydroxy-6-methoxybenzoic acid

Modify Date: 2024-01-08 05:40:17

2-Hydroxy-6-methoxybenzoic acid Structure
2-Hydroxy-6-methoxybenzoic acid structure
Common Name 2-Hydroxy-6-methoxybenzoic acid
CAS Number 3147-64-6 Molecular Weight 168.147
Density 1.4±0.1 g/cm3 Boiling Point 330.4±27.0 °C at 760 mmHg
Molecular Formula C8H8O4 Melting Point 134-138
MSDS Chinese USA Flash Point 138.7±17.2 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 2-Hydroxy-6-methoxybenzoic acid


2-Hydroxy-6-methoxybenzoic acid can be used for the determination of acetylsalicylic acid and its major metabolite, salicylic acid, in animal plasma. 2-Hydroxy-6-methoxybenzoic acid exhibits significant analgesic effects[1][2].

 Names

Name 2-hydroxy-6-methoxybenzoic acid
Synonym More Synonyms

 2-Hydroxy-6-methoxybenzoic acid Biological Activity

Description 2-Hydroxy-6-methoxybenzoic acid can be used for the determination of acetylsalicylic acid and its major metabolite, salicylic acid, in animal plasma. 2-Hydroxy-6-methoxybenzoic acid exhibits significant analgesic effects[1][2].
Related Catalog
References

[1]. Xu X, et al. Rapid and sensitive determination of acetylsalicylic acid and salicylic acid in plasma using liquid chromatography-tandem mass spectrometry: application to pharmacokinetic study. Biomed Chromatogr. 2009 Sep;23(9):973-9.

[2]. Palacios-Espinosa F, et al. Antinociceptive, hypoglycemic and spasmolytic effects of Brickellia veronicifolia. J Ethnopharmacol. 2008 Aug 13;118(3):448-54.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 330.4±27.0 °C at 760 mmHg
Melting Point 134-138
Molecular Formula C8H8O4
Molecular Weight 168.147
Flash Point 138.7±17.2 °C
Exact Mass 168.042252
PSA 66.76000
LogP 1.78
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.586

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
HS Code 2918990090

 Synthetic Route

~72%

2-Hydroxy-6-methoxybenzoic acid Structure

2-Hydroxy-6-met...

CAS#:3147-64-6

Literature: Kuehnert, Sven M; Maier, Martin E Organic letters, 2002 , vol. 4, # 4 p. 643 - 646

~60%

2-Hydroxy-6-methoxybenzoic acid Structure

2-Hydroxy-6-met...

CAS#:3147-64-6

Literature: Kung; Kasliwal; Pan; Mach; Guo Journal of Medicinal Chemistry, 1988 , vol. 31, # 5 p. 1039 - 1043

~35%

2-Hydroxy-6-methoxybenzoic acid Structure

2-Hydroxy-6-met...

CAS#:3147-64-6

Literature: Lamotte; Demerseman; Royer; et al. European Journal of Medicinal Chemistry, 1986 , vol. 21, # 5 p. 379 - 383

~%

2-Hydroxy-6-methoxybenzoic acid Structure

2-Hydroxy-6-met...

CAS#:3147-64-6

Literature: Journal of the American Chemical Society, , vol. 93, p. 3237 - 3248

~%

2-Hydroxy-6-methoxybenzoic acid Structure

2-Hydroxy-6-met...

CAS#:3147-64-6

Literature: Journal of the Chemical Society, , p. 2434,2439

 Customs

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles3

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Molecularly imprinted polymers with synthetic dummy template for simultaneously selective removal and enrichment of ginkgolic acids from Ginkgo biloba L. leaves extracts.

J. Chromatogr. A. 1368 , 44-51, (2014)

Dummy molecularly imprinted polymers (DMIPs) for simultaneously selective removal and enrichment of ginkgolic acids (GAs) during the processing of Ginkgo biloba leaves have been prepared. Two dummy te...

Rapid and sensitive determination of acetylsalicylic acid and salicylic acid in plasma using liquid chromatography-tandem mass spectrometry: application to pharmacokinetic study.

Biomed. Chromatogr. 23(9) , 973-9, (2009)

A simple and sensitive analytical method using liquid chromatography-tandem mass spectrometry (LC/MS/MS) for determination of acetylsalicylic acid (aspirin, ASA) and its major metabolite, salicylic ac...

Antinociceptive, hypoglycemic and spasmolytic effects ofBrickellia veronicifolia

J. Ethnopharmacol. 118(3) , 448-54, (2008)

Introduction Brickellia veronicifolia (Kunth) Gray (Asteraceae) (BV) is broadly commercialized for treating gastrointestinal diseases (stomach aches, biliary colics and dyspepsia), arthritis, diabetes...

 Synonyms

Benzoic acid, 2-hydroxy-6-methoxy-
2-hydroxy-6-methoxy-benzoic acid
6-hydroxy-2-methoxybenzoic acid
2-Carboxy-3-methoxyphenol
MFCD00674090
6-Methoxysalicylic Acid
6-Hydroxy-o-anisic Acid
2-Hydroxy-6-methoxybenzoic acid
5-methoxysalicylic acid