4-hydroxyestrone

Modify Date: 2024-01-02 15:16:33

4-hydroxyestrone structure	Common Name	4-hydroxyestrone
	CAS Number	3131-23-5	Molecular Weight	286.36500
	Density	1.241g/cm3	Boiling Point	468.2ºC at 760mmHg
	Molecular Formula	C₁₈H₂₂O₃	Melting Point	260-263ºC
	MSDS	Chinese USA	Flash Point	251.1ºC

Use of 4-hydroxyestrone

4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity[1].

Name	4-hydroxyestrone
Synonym	More Synonyms

Description	4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity[1].
Related Catalog	Research Areas >> Neurological Disease
Target	Human Endogenous Metabolite
References	[1]. Hye Joung Choi, et al. 4-Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells Against Oxidative Damage. Sci Rep. 2020 Apr 29;10(1):7283.

Density	1.241g/cm3
Boiling Point	468.2ºC at 760mmHg
Melting Point	260-263ºC
Molecular Formula	C₁₈H₂₂O₃
Molecular Weight	286.36500
Flash Point	251.1ºC
Exact Mass	286.15700
PSA	57.53000
LogP	3.52300
Index of Refraction	1.61
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KG7749500

CHEMICAL NAME :: Estra-1,3,5(10)-trien-17-one, 3,4-dihydroxy-

CAS REGISTRY NUMBER :: 3131-23-5

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H22-O3

MOLECULAR WEIGHT :: 286.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 30 mg/kg

SEX/DURATION :: female 1-6 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963- Volume(issue)/page/year: 30,343,1977

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	KG7749500

Precursor 9
CAS#:53-16-7 Estrone CAS#:210096-74-5 4,5-Epoxy-5β-es... CAS#:14984-42-0 Estra-1,3,5(10)... CAS#:5976-74-9 Estra-1,3,5(10)...
CAS#:74040-94-1 sodium salt of ... CAS#:5976-62-5 4-hydroxyestron... CAS#:210096-72-3 4,5-Epoxy-5α-es... CAS#:734-32-7 Bolandione
CAS#:81319-72-4 4,5-Epoxy-5β-es...
DownStream 4
CAS#:5976-61-4 4-hydroxyestradiol CAS#:58562-33-7 4-Hydroxyestron... CAS#:5976-62-5 4-hydroxyestron... CAS#:26624-38-4 3,4-Dimethoxyes...

Improved profiling of estrogen metabolites by orbitrap LC/MS.

Steroids 99 , 84-90, (2015)

Estrogen metabolites are important biomarkers to evaluate cancer risks and metabolic diseases. Due to their low physiological levels, a sensitive and accurate method is required, especially for the qu...

Redox cycling of catechol estrogens generating apurinic/apyrimidinic sites and 8-oxo-deoxyguanosine via reactive oxygen species differentiates equine and human estrogens.

Chem. Res. Toxicol. 23(8) , 1365-73, (2010)

Metabolic activation of estrogens to catechols and further oxidation to highly reactive o-quinones generates DNA damage including apurinic/apyrimidinic (AP) sites. 4-Hydroxyequilenin (4-OHEN) is the m...

Menstrual cycle effects on urinary estrogen metabolites.

J. Clin. Endocrinol. Metab. 84(11) , 3914-8, (1999)

Endogenous estrogen metabolism may play an important role in the pathogenesis of hormone-related cancers, most notably breast cancer. Despite the importance of estrogen metabolism, little is known abo...

4-Hydroxy Estrone

MFCD00079358

(8R,9S,13S,14S)-3,4-dihydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one

4-HydroxyEstrone

4-hydroxyestrone

Use of 4-hydroxyestrone

Names