CL-82198

Modify Date: 2024-01-08 22:12:27

CL-82198 structure	Common Name	CL-82198
	CAS Number	307002-71-7	Molecular Weight	302.37
	Density	N/A	Boiling Point	537.1ºC at 760 mmHg
	Molecular Formula	C₁₇H₂₂N₂O₃	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	278.6ºC
	Symbol	GHS07	Signal Word	Warning

Use of CL-82198

CL-82198 is a selective inhibitor of MMP-13.In vitro: In the presence of 10 and 20 μM of the specific MMP-13 inhibitor, CL-82198, migration of the LS174 cells was significantly reduced by 55 and 52%, respectively. . CL-82198 binds to the S1' pocket of MMP-13 leading to 89% enzyme inhibition at a concentration of 10 μg/ml. The addition of the specific MMP-13 inhibitor CL-82198 at a concentration of 10 μM resulted in a 45±5.6% reduction in the migration of LS174 cells.

Name	N-(4-morpholin-4-ylbutyl)-1-benzofuran-2-carboxamide,hydrochloride
Synonym	More Synonyms

Description	CL-82198 is a selective inhibitor of MMP-13.In vitro: In the presence of 10 and 20 μM of the specific MMP-13 inhibitor, CL-82198, migration of the LS174 cells was significantly reduced by 55 and 52%, respectively. . CL-82198 binds to the S1' pocket of MMP-13 leading to 89% enzyme inhibition at a concentration of 10 μg/ml. The addition of the specific MMP-13 inhibitor CL-82198 at a concentration of 10 μM resulted in a 45±5.6% reduction in the migration of LS174 cells.
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Research Areas >> Cancer
References	[1]. Rath T et al. Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration. Oncol Lett. 2011 May;2(3):483-488. [2]. Wohlauer M et al. Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit Care Med. 2012 Sep;40(9):2647-53.

Description

Related Catalog

Signaling Pathways >> Metabolic Enzyme/Protease >> MMP

Research Areas >> Cancer

References

[1]. Rath T et al. Matrix metalloproteinase-13 is regulated by toll-like receptor-9 in colorectal cancer cells and mediates cellular migration. Oncol Lett. 2011 May;2(3):483-488.

[2]. Wohlauer M et al. Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13. Crit Care Med. 2012 Sep;40(9):2647-53.

Boiling Point	537.1ºC at 760 mmHg
Molecular Formula	C₁₇H₂₂N₂O₃
Molecular Weight	302.37
Flash Point	278.6ºC
PSA	54.71000
LogP	3.40580
Storage condition	2-8℃

CL-82198 MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
RIDADR	NONH for all modes of transport
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

IN1376

N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide

CL-82198

DC Chemicals Limited
China
Product Name: CL-82198
Price: $250.0/100mg $500.0/250mg $1000.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CL 82198 HYDROCHLORIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $66/10mM*1mLinDMSO

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CL-82198

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