Didemethylclomipramine
Didemethylclomipramine structure
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Common Name | Didemethylclomipramine | ||
|---|---|---|---|---|
| CAS Number | 303-48-0 | Molecular Weight | 337.28700 | |
| Density | 1.129g/cm3 | Boiling Point | 439.5ºC at 760mmHg | |
| Molecular Formula | C18H22Cl2N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 219.6ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of DidemethylclomipramineDidemethylclomipramine (Norclomipramine, N-Desmethylcomipramine) is the major active metabolite of the tricyclic antidepressant (TCA) clomipramine. |
| Name | n-desmethylclomipramine hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Density | 1.129g/cm3 |
|---|---|
| Boiling Point | 439.5ºC at 760mmHg |
| Molecular Formula | C18H22Cl2N2 |
| Molecular Weight | 337.28700 |
| Flash Point | 219.6ºC |
| Exact Mass | 336.11600 |
| PSA | 15.27000 |
| LogP | 5.44410 |
| Index of Refraction | 1.583 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | 20/21/22 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
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Didemethylclomi... CAS#:303-48-0 |
| Literature: Chaudhuri, Naba K.; Servando, Ofelia; Markus, Bohdan; Galynker, Igor; Sung, Ming-Sang Journal of the Indian Chemical Society, 1985 , vol. 62, # 11 p. 899 - 903 |
| Precursor 1 | |
|---|---|
| DownStream 0 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Steady state concentrations of clomipramine and its major metabolite desmethylclomipramine in rat brain and serum after oral administration of clomipramine.
Eur. Neuropsychopharmacol. 10(5) , 401-5, (2000) Twenty male Sprague-Dawley rats received five oral doses of clomipramine 20 mg/kg at 4-h intervals. The animals were decapitated 1, 2, 3, 5 and 12 h after the last dose for determination of clomiprami... |
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Clinical significance of plasma levels of clomipramine, its hydroxylated and desmethylated metabolites: prediction of clinical outcome in mood disorders using discriminant analysis of therapeutic drug monitoring data.
J. Affect. Disord. 29(4) , 267-79, (1993) We measured the plasma concentrations of clomipramine and its metabolites, N-desmethylclompiramine, 8-hydroxy-N-desmethylclomipramine, 8-hydroxyclomipramine in 65 depressed patients with subtypes of D... |
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Pharmacokinetics of clomipramine in dogs following single-dose and repeated-dose oral administration.
Am. J. Vet. Res. 61(1) , 80-5, (2000) To determine pharmacokinetics of clomipramine and its principle metabolite (desmethylclomipramine) in the plasma of dogs following single-dose and repeated-dose oral administration at various dosages.... |
| Demethylchlorimipramine |
| [3-(3-chloro-10,11-dihydro-dibenzo[b,f]azepin-5-yl)-propyl]-methyl-amine |
| N-Desmethylclomipramine HCl |
| Norclomipramine |
| n-desmethylclomipramine |
| Chlordesipramine |
| desmethylclomipramine |
| N-Demethylclomipramine |
| N-Desmethylchlomipramine |
| Desmethylchlomipramine |
| Demethylchlomipramine |
| Desmethylchlorimipramine |