DUPA
Modify Date: 2024-01-02 17:23:34
DUPA structure
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Common Name | DUPA | ||
|---|---|---|---|---|
| CAS Number | 302941-52-2 | Molecular Weight | 320.25 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H16N2O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DUPADUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in drug conjugate to selectively deliver cytotoxic drugs to prostate cancer cells[1][2]. |
| Name | DUPA |
|---|
| Description | DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in drug conjugate to selectively deliver cytotoxic drugs to prostate cancer cells[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of prostate-specific membrane antigen (PSMA) expressing prostate cancer[1]. The DUPA-indenoisoquinoline conjugate exhibits an IC50 in the low nanomolar range in 22RV1 cell cultures[2]. |
| In Vivo | The DUPA-indenoisoquinoline conjugate induces a complete cessation of tumor growth with no toxicity, as determined by loss of body weight and death of treated mice[2]. |
| References |
| Molecular Formula | C11H16N2O9 |
|---|---|
| Molecular Weight | 320.25 |