DUPA(OtBu)-OH
Modify Date: 2024-01-02 21:20:34
DUPA(OtBu)-OH structure
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Common Name | DUPA(OtBu)-OH | ||
|---|---|---|---|---|
| CAS Number | 1026987-94-9 | Molecular Weight | 488.57 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H40N2O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DUPA(OtBu)-OHDUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer. |
| Name | DUPA(OtBu)-OH |
|---|
| Description | DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer. |
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| Related Catalog | |
| In Vitro | DUPA(OtBu)-OH (DUPA precursor 17) is a 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA) reagent[1]. The targeting ligand DUPA enhances the transport capability and selectivity of Paclitaxel (PTX) to tumor cells via prostate-specific membrane antigen (PSMA) mediated endocytosis. Besides, DUPA is conjugated with PTX via a disulfide bond, which facilitates the rapid and differential drug release in tumor cells[2]. |
| In Vivo | DUPA-targeted Docetaxel (DTX) conjugate with longer spacer has no toxicity in major organs of treated mice[3]. |
| References |
| Molecular Formula | C23H40N2O9 |
|---|---|
| Molecular Weight | 488.57 |