302941-52-2
302941-52-2 structure
- Name: DUPA
- Chemical Name: DUPA
- CAS Number: 302941-52-2
- Molecular Formula: C11H16N2O9
- Molecular Weight: 320.25
- Catalog: Research Areas Cancer
- Create Date: 2019-06-02 12:57:56
- Modify Date: 2025-08-25 22:31:11
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DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in drug conjugate to selectively deliver cytotoxic drugs to prostate cancer cells[1][2].
| Name | DUPA |
|---|
| Description | DUPA, belongs to a class of glutamate ureas, is used as the targeting moiety in drug conjugate to selectively deliver cytotoxic drugs to prostate cancer cells[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of prostate-specific membrane antigen (PSMA) expressing prostate cancer[1]. The DUPA-indenoisoquinoline conjugate exhibits an IC50 in the low nanomolar range in 22RV1 cell cultures[2]. |
| In Vivo | The DUPA-indenoisoquinoline conjugate induces a complete cessation of tumor growth with no toxicity, as determined by loss of body weight and death of treated mice[2]. |
| References |
| Molecular Formula | C11H16N2O9 |
|---|---|
| Molecular Weight | 320.25 |