4-CMTB

Modify Date: 2024-01-14 09:39:56

4-CMTB structure	Common Name	4-CMTB
	CAS Number	300851-67-6	Molecular Weight	294.80000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₁₅ClN₂OS	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Use of 4-CMTB

4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC50=6.38)[1].

Name	2-(4-Chlorophenyl)-3-methyl-N-(1,3-thiazol-2-yl)butanamide

Description	4-CMTB is a selective free fatty acid receptor 2 (FFA2/GPR43) agonist and a positive allosteric modulator (pEC50=6.38)[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	4-CMTB is both a direct agonist and a positive allosteric modulator of the action of short-chain free fatty acids. 4-CMTB modulates the activity of short-chain fatty acids at FFA2 via the FFA2 second extracellular loop (ECL2)[1][2].
References	[1]. Smith NJ, et al. Extracellular loop 2 of the free fatty acid receptor 2 mediates allosterism of a phenylacetamide ago-allosteric modulator. Mol Pharmacol. 2011;80(1):163-173. [2]. Milligan G, Stoddart LA, Smith NJ. Agonism and allosterism: the pharmacology of the free fatty acid receptors FFA2 and FFA3. Br J Pharmacol. 2009;158(1):146-153.

Molecular Formula	C₁₄H₁₅ClN₂OS
Molecular Weight	294.80000
Exact Mass	294.05900
PSA	73.72000
LogP	4.82430
Storage condition	2-8°C

4-CMTB MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
RIDADR	NONH for all modes of transport

2-Aminothiazole structure

2-Aminothiazole

CAS#:96-50-4

2-(p-Chlorophenyl)-3-methylbutyric Acid structure

2-(p-Chlorophen...

CAS#:2012-74-0

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4-CMTB Structure

4-CMTB

CAS#:300851-67-6

Literature: Wang, Yingcai; Jiao, Xianyun; Kayser, Frank; Liu, Jiwen; Wang, Zhongyu; Wanska, Malgorzata; Greenberg, Joanne; Weiszmann, Jennifer; Ge, Hongfei; Tian, Hui; Wong, Simon; Schwandner, Ralf; Lee, Taeweon; Li, Yang Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 2 p. 493 - 498

DC Chemicals Limited
China
Product Name: 4-CMTB
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-Chloro-α-(1-methylethyl)-N-2-thiazolyl-benzeneacetamide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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