Bronidox

Modify Date: 2024-01-02 12:37:42

Bronidox structure	Common Name	Bronidox
	CAS Number	30007-47-7	Molecular Weight	211.999
	Density	1.8±0.1 g/cm3	Boiling Point	280.8±40.0 °C at 760 mmHg
	Molecular Formula	C₄H₆BrNO₄	Melting Point	60°C
	MSDS	Chinese USA	Flash Point	123.6±27.3 °C
	Symbol	GHS07	Signal Word	Warning

Use of Bronidox

5-Bromo-5-nitro-1,3-dioxane, an antimicrobial compound, is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast. 5-Bromo-5-nitro-1,3-dioxane inhibits enzyme activity and subsequent inhibition of microbial growth by the oxidation of essential protein thiol[1].

Name	5-Bromo-5-nitro-1,3-dioxane
Synonym	More Synonyms

Description	5-Bromo-5-nitro-1,3-dioxane, an antimicrobial compound, is effective against Gram-positive and Gram-negative bacteria and fungi, including yeast. 5-Bromo-5-nitro-1,3-dioxane inhibits enzyme activity and subsequent inhibition of microbial growth by the oxidation of essential protein thiol[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. M Ghannoum, et al. Mode of Action of the Antimicrobial Compound 5-bromo-5-nitro-1,3-dioxane (Bronidox). Folia Microbiol (Praha). 1986;31(1):19-31.

Density	1.8±0.1 g/cm3
Boiling Point	280.8±40.0 °C at 760 mmHg
Melting Point	60°C
Molecular Formula	C₄H₆BrNO₄
Molecular Weight	211.999
Flash Point	123.6±27.3 °C
Exact Mass	210.948013
PSA	64.28000
LogP	0.95
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.533

Bronidox MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JG9650000

CHEMICAL NAME :: m-Dioxane, 5-bromo-5-nitro-

CAS REGISTRY NUMBER :: 30007-47-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C4-H6-Br-N-O4

MOLECULAR WEIGHT :: 212.02

WISWESSER LINE NOTATION :: T6O COTJ EE ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 455 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 31 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 590 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Skin and Appendages - dermatitis, other (after systemic exposure)

REFERENCE :: FSASAX Fette, Seifen, Anstrichmittel. (Industrieverlag von Hernhaussen KG, Postfach 100252, D-7022 Leinfelden-Echterdingen 1, Fed. Rep. Ger.) V.55- 1953- Volume(issue)/page/year: 78,269,1976

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R22;R38
Safety Phrases	S36
RIDADR	1759
WGK Germany	3
RTECS	JG9650000
HS Code	2934999090

Formaldehyde

CAS#:50-00-0

bronopol

CAS#:52-51-7

~67%

Bronidox

CAS#:30007-47-7

Literature: Eccles, Wendy; Jasinski, Marcin; Kaszynski, Piotr; Zienkiewicz, Katarzyna; Stulgies, Baldur; Jankowiak, Aleksandra Journal of Organic Chemistry, 2008 , vol. 73, # 15 p. 5732 - 5744

Precursor 2
CAS#:50-00-0 Formaldehyde CAS#:52-51-7 bronopol
DownStream 6
CAS#:3964-18-9 2,3-DIMETHYL-2,... CAS#:91173-72-7 5-nitro-5-(2-ni... CAS#:86251-74-3 5-nitro-5-(5-ni... CAS#:110-81-6 Diethyl disulfide
CAS#:86251-75-4 5-(1,3-dioxan-5... CAS#:4064-86-2 5-nitro-1,3-dioxane

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Mode of action of the antimicrobial compound 5-bromo-5-nitro-1,3-dioxane (bronidox).

Folia Microbiol. (Praha) 31 , 19-31, (1986)

The mode of action of the antimicrobial agent, 5-bromo-5-nitro-1,3-dioxane (bronidox), was studied in detail for gram-positive and gram-negative bacteria, yeast and fungi. The studies included MIC tes...

EINECS 250-001-7

5-bromo-5-nitro-1,3-dioxolane

5-Bromo-5-nitro-m-dioxane

5-bromo-5-nitro-1,3-dioxan

5-Bromo-5-nitro-1,3-dioxane

1,3-Dioxane, 5-bromo-5-nitro-

m-Dioxane, 5-bromo-5-nitro-

MFCD00101855

m-DIOXANE,5-BROMO-5-NITRO

1,3-Dioxane,5-bromo-5-nitro

Bronidox

5-Bromo-5-nitro-1.3-dioxane

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Bronidox
Price: ￥498.0/5g ￥798.0/25g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Bronidox
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-Bromo-5-nitro-1,3-dioxane
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 5-bromo-5-nitro-1,3-dioxane 30007-47-7
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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Bronidox

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