GPX4-IN-6

Modify Date: 2024-04-09 18:08:42

GPX4-IN-6 Structure
GPX4-IN-6 structure
Common Name GPX4-IN-6
CAS Number 2922824-07-3 Molecular Weight 426.23
Density N/A Boiling Point N/A
Molecular Formula C18H17BrFNO5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GPX4-IN-6


GPX4-IN-6 (Compound C25) is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM. GPX4-IN-6 (Compound C25) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) [1].

 Names

Name GPX4-IN-6

 GPX4-IN-6 Biological Activity

Description GPX4-IN-6 (Compound C25) is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM. GPX4-IN-6 (Compound C25) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) [1].
Related Catalog
Target

IC50: 0.13 μM (GPX4)[1]

References

[1]. Chen T, et al. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66(14):10036-10059.

 Chemical & Physical Properties

Molecular Formula C18H17BrFNO5
Molecular Weight 426.23