GPX4-IN-6

Names

[ Name ]:
GPX4-IN-6

Biological Activity

[Description]:

GPX4-IN-6 (Compound C25) is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM. GPX4-IN-6 (Compound C25) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) [1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> Ferroptosis

[Target]

IC50: 0.13 μM (GPX4)[1]

[References]

[1]. Chen T, et al. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66(14):10036-10059.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₇BrFNO₅

[ Molecular Weight ]:
426.23

Related Compounds

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