S-Methyl glutathione

Modify Date: 2025-08-23 17:44:58

S-Methyl glutathione Structure
S-Methyl glutathione structure
Common Name S-Methyl glutathione
CAS Number 2922-56-7 Molecular Weight 321.35000
Density N/A Boiling Point N/A
Molecular Formula C11H19N3O6S Melting Point N/A
MSDS Chinese USA Flash Point N/A

 Use of S-Methyl glutathione


S-Methylglutathione is an S-substitued glutathione and a stronger nucleophile than GSH[1]. S-Methylglutathione has inhibitory effect on glyoxalase 1[2].

 Names

Name S-Methylglutathione
Synonym More Synonyms

 S-Methyl glutathione Biological Activity

Description S-Methylglutathione is an S-substitued glutathione and a stronger nucleophile than GSH[1]. S-Methylglutathione has inhibitory effect on glyoxalase 1[2].
Related Catalog
In Vitro S-Methylglutathione (GS-Me) is a stronger nucleophile than GSH, which is rationalized by the more positive inductive effect of the methyl group[1].
References

[1]. Foye WO, et al. Synthesis and evaluation of N-alkanoyl-S-benzyl-L-cysteinylglutamic acid esters as glyoxalase I inhibitors and anticancer agents. J Pharm Sci. 1984 Apr;73(4):559-61.

[2]. Milos I. Djuran,et al. Reactivity of chloro- and aqua(diethylenetriamine)platinum(II) ions with glutathione, S-methylglutathione, and guanosine 5'-monophosphate in relation to the antitumor activity and toxicity of platinum complexes. Inorg. Chem. 1991, 30, 12, 2648–2652

 Chemical & Physical Properties

Molecular Formula C11H19N3O6S
Molecular Weight 321.35000
Exact Mass 321.09900
PSA 191.10000
LogP 0.60800
Vapour Pressure 1.23E-25mmHg at 25°C
InChIKey QTQDDTSVRVWHMO-BQBZGAKWSA-N
SMILES CSCC(NC(=O)CCC(N)C(=O)O)C(=O)NCC(=O)O
Storage condition 2~8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3.0
HS Code 2930909090

 Customs

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles25

More Articles
Crystallographic and thermodynamic analysis of the binding of S-octylglutathione to the Tyr 7 to Phe mutant of glutathione S-transferase from Schistosoma japonicum.

Biochemistry 44 , 1174-1183, (2005)

Glutathione S-transferases are a family of multifunctional enzymes involved in the metabolism of drugs and xenobiotics. Two tyrosine residues, Tyr 7 and Tyr 111, in the active site of the enzyme play ...

Calcium-sensing receptor-dependent activation of CREB phosphorylation in HEK293 cells and human parathyroid cells.

Am. J. Physiol. Endocrinol. Metab. 304(10) , E1097-104, (2013)

In addition to its acute effects on hormone secretion, epithelial transport, and shape change, the calcium-sensing receptor (CaSR) modulates the expression of genes that control cell survival, prolife...

3-Methyleneoxindole: an affinity label of glutathione S-transferase pi which targets tryptophan 38.

Biochemistry 40(25) , 7549-58, (2001)

The compound 3-methyleneoxindole (MOI), a photooxidation product of the plant auxin indole-3-acetic acid, functions as an affinity label of the dimeric pi class glutathione S-transferase (GST) isolate...

 Synonyms

(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-methylsulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
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