Cisd2 agonist 2

Modify Date: 2025-08-25 08:23:29

Cisd2 agonist 2 Structure
Cisd2 agonist 2 structure
Common Name Cisd2 agonist 2
CAS Number 2916371-59-8 Molecular Weight 306.34
Density N/A Boiling Point N/A
Molecular Formula C14H14N2O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cisd2 agonist 2


Cisd2 agonist 2 (compound 6) is an orally active Cisd2 activator (EC50=191 nM), while the Cisd2 levels is correlated with nonalcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant toxicity in vivo in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout)[1].

 Names

Name Cisd2 agonist 2

 Cisd2 agonist 2 Biological Activity

Description Cisd2 agonist 2 (compound 6) is an orally active Cisd2 activator (EC50=191 nM), while the Cisd2 levels is correlated with nonalcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant toxicity in vivo in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout)[1].
Related Catalog
Target

CDGSH iron sulfur domain-containing 2 (Cisd2)[1]

References

[1]. Yao CH, et al. Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease. Eur J Med Chem. 2023 Oct 5;258:115583.  

 Chemical & Physical Properties

Molecular Formula C14H14N2O4S
Molecular Weight 306.34
InChIKey RUKNSHPYDAPFMK-UHFFFAOYSA-N
SMILES COC(=O)c1c(N)sc(C(=O)Nc2ccc(O)cc2)c1C
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