Cisd2 agonist 2

Names

[ CAS No. ]:
2916371-59-8

[ Name ]:
Cisd2 agonist 2

Biological Activity

[Description]:

Cisd2 agonist 2 (compound 6) is an orally active Cisd2 activator (EC50=191 nM), while the Cisd2 levels is correlated with nonalcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant toxicity in vivo in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout)[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[Target]

CDGSH iron sulfur domain-containing 2 (Cisd2)[1]


[References]

[1]. Yao CH, et al. Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease. Eur J Med Chem. 2023 Oct 5;258:115583.  

Chemical & Physical Properties

[ Molecular Formula ]:
C14H14N2O4S

[ Molecular Weight ]:
306.34

Related Compounds

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