DprE1-IN-9

Modify Date: 2025-09-27 11:07:00

DprE1-IN-9 Structure
DprE1-IN-9 structure
Common Name DprE1-IN-9
CAS Number 2906099-98-5 Molecular Weight 434.45
Density N/A Boiling Point N/A
Molecular Formula C22H25F3N4O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DprE1-IN-9


DprE1-IN-9 (compound B18) is an effective reversible DprE1 inhibitor and can bind to the receptor cavity of DprE1. DprE1-IN-9 shows strong antimycobacterial activity not only against non-pathogenic strain H37Ra (MIC=0.18 µg/mL) but also against pathogenic H37Rv and the clinical MDR and XDR isolates[1].

 Names

Name DprE1-IN-9

 DprE1-IN-9 Biological Activity

Description DprE1-IN-9 (compound B18) is an effective reversible DprE1 inhibitor and can bind to the receptor cavity of DprE1. DprE1-IN-9 shows strong antimycobacterial activity not only against non-pathogenic strain H37Ra (MIC=0.18 µg/mL) but also against pathogenic H37Rv and the clinical MDR and XDR isolates[1].
Related Catalog
References

[1]. Wang Xiang, et al. Discovery of novel reversible inhibitor of DprE1 based on benzomorpholine for the treatment of tuberculosis. Microbiol Spectr. 2023 Sep 12:e0472122.  

 Chemical & Physical Properties

Molecular Formula C22H25F3N4O2
Molecular Weight 434.45
InChIKey HUQTWGBRMNYWHL-UHFFFAOYSA-N
SMILES Cc1nc(C)c(CN2CCOc3c(C(=O)NCC(F)(F)F)cc(C4CC4)cc32)nc1C
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