DprE1-IN-9

Names

[ Name ]:
DprE1-IN-9

Biological Activity

[Description]:

DprE1-IN-9 (compound B18) is an effective reversible DprE1 inhibitor and can bind to the receptor cavity of DprE1. DprE1-IN-9 shows strong antimycobacterial activity not only against non-pathogenic strain H37Ra (MIC=0.18 µg/mL) but also against pathogenic H37Rv and the clinical MDR and XDR isolates[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Wang Xiang, et al. Discovery of novel reversible inhibitor of DprE1 based on benzomorpholine for the treatment of tuberculosis. Microbiol Spectr. 2023 Sep 12:e0472122.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₅F₃N₄O₂

[ Molecular Weight ]:
434.45

Related Compounds

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