S-(4-fluorophenyl) 4-fluorobenzenesulfonothioate

Modify Date: 2024-01-14 06:00:33

S-(4-fluorophenyl) 4-fluorobenzenesulfonothioate Structure
S-(4-fluorophenyl) 4-fluorobenzenesulfonothioate structure
Common Name S-(4-fluorophenyl) 4-fluorobenzenesulfonothioate
CAS Number 2905-15-9 Molecular Weight 286.31800
Density N/A Boiling Point N/A
Molecular Formula C12H8F2O2S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of S-(4-fluorophenyl) 4-fluorobenzenesulfonothioate


Tubulin inhibitor 29 (compound 3c) is a potent tubulin inhibitor with an IC50 value of 1.2 µM. Tubulin inhibitor 29 shows antiproliferative effects with an IC50 value of 7.5 µM for MCF-7 cells. Tubulin inhibitor 29 inhibits tubulin assembly and bounds in the colchicine site[1].

 Names

Name S-(4-fluorophenyl) 4-fluorobenzenesulfonothioate
Synonym More Synonyms

  Biological Activity

Description Tubulin inhibitor 29 (compound 3c) is a potent tubulin inhibitor with an IC50 value of 1.2 µM. Tubulin inhibitor 29 shows antiproliferative effects with an IC50 value of 7.5 µM for MCF-7 cells. Tubulin inhibitor 29 inhibits tubulin assembly and bounds in the colchicine site[1].
Related Catalog
Target

IC50: 1.2 µM (tubulin)[1].

References

[1]. Khodyuk RGD, et al. Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity. Bioorg Chem. 2020 Aug;101:104017.

 Chemical & Physical Properties

Molecular Formula C12H8F2O2S2
Molecular Weight 286.31800
Exact Mass 285.99300
PSA 67.82000
LogP 4.52660

 Synonyms

S-p-fluorophenyl p-fluorobenzenethiosulfonate
p,p'-Di-fluor-phenylsulfonylthiophenol
p-Fluorphenyl-p-fluorbenzolthiosulfonat
S-4-fluorophenyl 4-fluorobenzenesulfonothioate
S-4-fluorophenyl 4-fluorobenzenethiosulfonate