2905-15-9

2905-15-9 structure

Name: S-(4-fluorophenyl) 4-fluorobenzenesulfonothioate
Chemical Name: S-(4-fluorophenyl) 4-fluorobenzenesulfonothioate
CAS Number: 2905-15-9
Molecular Formula: C₁₂H₈F₂O₂S₂
Molecular Weight: 286.31800
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2017-06-06 15:35:17
Modify Date: 2024-01-14 06:00:33
Tubulin inhibitor 29 (compound 3c) is a potent tubulin inhibitor with an IC50 value of 1.2 µM. Tubulin inhibitor 29 shows antiproliferative effects with an IC50 value of 7.5 µM for MCF-7 cells. Tubulin inhibitor 29 inhibits tubulin assembly and bounds in the colchicine site[1].

Name	S-(4-fluorophenyl) 4-fluorobenzenesulfonothioate
Synonyms	S-p-fluorophenyl p-fluorobenzenethiosulfonate p,p'-Di-fluor-phenylsulfonylthiophenol p-Fluorphenyl-p-fluorbenzolthiosulfonat S-4-fluorophenyl 4-fluorobenzenesulfonothioate S-4-fluorophenyl 4-fluorobenzenethiosulfonate

Description	Tubulin inhibitor 29 (compound 3c) is a potent tubulin inhibitor with an IC50 value of 1.2 µM. Tubulin inhibitor 29 shows antiproliferative effects with an IC50 value of 7.5 µM for MCF-7 cells. Tubulin inhibitor 29 inhibits tubulin assembly and bounds in the colchicine site[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	IC50: 1.2 µM (tubulin)[1].
References	[1]. Khodyuk RGD, et al. Diaryl disulfides and thiosulfonates as combretastatin A-4 analogues: Synthesis, cytotoxicity and antitubulin activity. Bioorg Chem. 2020 Aug;101:104017.