pan-KRAS-IN-2

Modify Date: 2025-08-26 10:07:17

pan-KRAS-IN-2 structure	Common Name	pan-KRAS-IN-2
	CAS Number	2882825-14-9	Molecular Weight	584.66
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₄H₃₄F₂N₄O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of pan-KRAS-IN-2

pan-KRAS-IN-2 (compound 6) is a pan inhibitor of with IC50s ≤10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A, Q61H), and ＞10 μM for KRAS G13D, respectively[1].

Name	pan-KRAS-IN-2

Description	pan-KRAS-IN-2 (compound 6) is a pan inhibitor of with IC50s ≤10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A, Q61H), and ＞10 μM for KRAS G13D, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	IC50: ≤10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A, Q61H), and ＞10 μM for KRAS G13D
References	[1]. Jones C, et al. Quinazoline derivatives useful as Ras inhibitors and their preparation. World Intellectual Property Organization, WO2022258974 A1. 2022-12-15.

Molecular Formula	C₃₄H₃₄F₂N₄O₃
Molecular Weight	584.66
InChIKey	HYCYHHMWGDUNSM-NHOCJEJCSA-N
SMILES	C#Cc1c(F)ccc2cc(O)cc(-c3ccc4c(N5CCCOCC5)nc(OCC56CCCN5CC(F)C6)nc4c3C)c12

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