pan-KRAS-IN-2

Names

[ Name ]:
pan-KRAS-IN-2

Biological Activity

[Description]:

pan-KRAS-IN-2 (compound 6) is a pan inhibitor of with IC50s ≤10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A, Q61H), and ＞10 μM for KRAS G13D, respectively[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

IC50: ≤10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A, Q61H), and ＞10 μM for KRAS G13D

[References]

[1]. Jones C, et al. Quinazoline derivatives useful as Ras inhibitors and their preparation. World Intellectual Property Organization, WO2022258974 A1. 2022-12-15.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₄H₃₄F₂N₄O₃

[ Molecular Weight ]:
584.66

Related Compounds

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