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2882825-14-9

2882825-14-9 structure

2882825-14-9 structure

Name: pan-KRAS-IN-2
Chemical Name: pan-KRAS-IN-2
CAS Number: 2882825-14-9
Molecular Formula: C₃₄H₃₄F₂N₄O₃
Molecular Weight: 584.66
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2023-11-25 07:34:34
Modify Date: 2024-01-14 16:45:11
pan-KRAS-IN-2 (compound 6) is a pan inhibitor of with IC50s ≤10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A, Q61H), and ＞10 μM for KRAS G13D, respectively[1].

Name	pan-KRAS-IN-2

Description	pan-KRAS-IN-2 (compound 6) is a pan inhibitor of with IC50s ≤10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A, Q61H), and ＞10 μM for KRAS G13D, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	IC50: ≤10 nM for KRAS WT and mutants (G12D, G12C, G12V, G12S, G12A, Q61H), and ＞10 μM for KRAS G13D
References	[1]. Jones C, et al. Quinazoline derivatives useful as Ras inhibitors and their preparation. World Intellectual Property Organization, WO2022258974 A1. 2022-12-15.

Molecular Formula	C₃₄H₃₄F₂N₄O₃
Molecular Weight	584.66

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