Bumetanide
Modify Date: 2024-01-02 15:56:47
Bumetanide structure
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Common Name | Bumetanide | ||
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| CAS Number | 28395-03-1 | Molecular Weight | 364.416 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 571.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C17H20N2O5S | Melting Point | 230-2310C | |
| MSDS | Chinese USA | Flash Point | 299.3±32.9 °C | |
Use of BumetanideBumetanide(Ro 10-6338; PF 1593) is an inhibitor of Na(+)-K(+)-2Cl(-) co-transporter (NKCC) with an IC50 of 0.6 uM.IC50 Value: 0.6 uM [1]Target: NKCC (Na-K-Cl cotransporter)in vitro: Cultured chick cardiac cells possess a Na+K+Cl-co-transport system that is inhibited by the "loop diuretics" bumetanide (IC50 = 0.6 microM). The K0.5 values for Cl- and Na+ activation of thebumetanide-sensitive 86Rb+ uptake are 59 mM and 40mM respectively. Bumetanide also inhibits a 22Na+ uptake component that is suppressed when external Cl- or K+ are substituted by impermeant ions. The ratio of bumetanide-sensitive 86Rb+ to 22Na+ uptake is close to 1. The cardiac Na+/K+/Cl- cotransport is a major uptake pathway for Na+ and K+ [1]. Bumetanide inhibits ouabain-resistant 86Rb(K+) influx with IC50of 0.1, 5.0, and 0.05 microM for J774.2, CT2 and J7H1 macrophages, respectively [2]. in vivo:Intraperitoneal injection of 50 or 100 mg bumetanide/kg body weight resulted in an acute and transient hyperglycaemia. Pretreatment with 240 mg probenecid/kg body weight reduced the diuretic effect but potentiated the hyperglycaemic effect of bumetanide (50 mg/kg body weight). The glucose tolerance was impaired, and there was an elevated serum glucose and glucose/insulin ratio 2 h after a single injection of bumetanide (100 mg/kg body weight) [3]. |
| Name | bumetanide |
|---|---|
| Synonym | More Synonyms |
| Description | Bumetanide(Ro 10-6338; PF 1593) is an inhibitor of Na(+)-K(+)-2Cl(-) co-transporter (NKCC) with an IC50 of 0.6 uM.IC50 Value: 0.6 uM [1]Target: NKCC (Na-K-Cl cotransporter)in vitro: Cultured chick cardiac cells possess a Na+K+Cl-co-transport system that is inhibited by the "loop diuretics" bumetanide (IC50 = 0.6 microM). The K0.5 values for Cl- and Na+ activation of thebumetanide-sensitive 86Rb+ uptake are 59 mM and 40mM respectively. Bumetanide also inhibits a 22Na+ uptake component that is suppressed when external Cl- or K+ are substituted by impermeant ions. The ratio of bumetanide-sensitive 86Rb+ to 22Na+ uptake is close to 1. The cardiac Na+/K+/Cl- cotransport is a major uptake pathway for Na+ and K+ [1]. Bumetanide inhibits ouabain-resistant 86Rb(K+) influx with IC50of 0.1, 5.0, and 0.05 microM for J774.2, CT2 and J7H1 macrophages, respectively [2]. in vivo:Intraperitoneal injection of 50 or 100 mg bumetanide/kg body weight resulted in an acute and transient hyperglycaemia. Pretreatment with 240 mg probenecid/kg body weight reduced the diuretic effect but potentiated the hyperglycaemic effect of bumetanide (50 mg/kg body weight). The glucose tolerance was impaired, and there was an elevated serum glucose and glucose/insulin ratio 2 h after a single injection of bumetanide (100 mg/kg body weight) [3]. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 571.2±60.0 °C at 760 mmHg |
| Melting Point | 230-2310C |
| Molecular Formula | C17H20N2O5S |
| Molecular Weight | 364.416 |
| Flash Point | 299.3±32.9 °C |
| Exact Mass | 364.109283 |
| PSA | 127.10000 |
| LogP | 2.78 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.612 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | DG4910000 |
| HS Code | 2935009090 |
| Precursor 2 | |
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| DownStream 1 | |
CAS#:32643-00-8
CAS#:28510-66-9
CAS#:28434-74-4| HS Code | 2935009090 |
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| Summary | 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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| 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid |
| Segurex |
| Benzoic acid, 3-(aminosulfonyl)-5-(butylamino)-4-phenoxy- |
| EINECS 249-004-6 |
| MFCD00078949 |
| 3-(aminosulfonyl)-5-(butylamino)-4-(phenyloxy)benzoic acid |
| Burinex |
| Lunetoron |
| Butinat |
| Bumetanidum |
| 2-phenoxy-3-butylamino-5-carboxybenzenesulfonamide |
| Bumex |
| 3-(butylamino-)-4-phenoxy-5-sulfamoylbenzoic acid |
| Bumetanida |
| [3H]-Bumetanide |
| Fordiuran |
| Bumetanide |
| Fontego |
| Lixil |
| 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Bumetanide
- Price: ￥678.0/250mg ￥1938.0/1g
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Bumetanide
- Price: $250.0/100mg $500.0/250mg $1000.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Bumetanide
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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Price: $117/10mM*1mLinDMSO
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