KY386

Modify Date: 2025-08-26 21:02:47

KY386 Structure
KY386 structure
Common Name KY386
CAS Number 2787598-01-8 Molecular Weight 405.47
Density N/A Boiling Point N/A
Molecular Formula C21H19N5O2S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of KY386


KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC50 of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability[1].

 Names

Name KY386

 KY386 Biological Activity

Description KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC50 of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability[1].
Related Catalog
Target

19 nM[1]

References

[1]. Wang Y, et al. Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents [published online ahead of print, 2023 Oct 12]. Bioorg Med Chem Lett. 2023;96:129505. doi:10.1016/j.bmcl.2023.129505  

 Chemical & Physical Properties

Molecular Formula C21H19N5O2S
Molecular Weight 405.47
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