KY386

Names

[ Name ]:
KY386

Biological Activity

[Description]:

KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC50 of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

19 nM[1]

[References]

[1]. Wang Y, et al. Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents [published online ahead of print, 2023 Oct 12]. Bioorg Med Chem Lett. 2023;96:129505. doi:10.1016/j.bmcl.2023.129505

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₁₉N₅O₂S

[ Molecular Weight ]:
405.47

Related Compounds

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