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2787598-01-8

2787598-01-8 structure
2787598-01-8 structure
  • Name: KY386
  • Chemical Name: KY386
  • CAS Number: 2787598-01-8
  • Molecular Formula: C21H19N5O2S
  • Molecular Weight: 405.47
  • Catalog: Research Areas Cancer
  • Create Date: 2024-03-08 12:26:55
  • Modify Date: 2025-08-26 21:02:47
  • KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC50 of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability[1].

Name KY386
Description KY386 is a potent, selective inhibitor of DHX33 helicase, with the IC50 of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability[1].
Related Catalog
Target

19 nM[1]

References

[1]. Wang Y, et al. Development of small molecule inhibitors targeting RNA helicase DHX33 as anti-cancer agents [published online ahead of print, 2023 Oct 12]. Bioorg Med Chem Lett. 2023;96:129505. doi:10.1016/j.bmcl.2023.129505  

Molecular Formula C21H19N5O2S
Molecular Weight 405.47
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