L-Glutamic acid-d5

Modify Date: 2025-08-23 18:04:04

L-Glutamic acid-d5 Structure
L-Glutamic acid-d5 structure
Common Name L-Glutamic acid-d5
CAS Number 2784-50-1 Molecular Weight 152.160
Density 1.4±0.1 g/cm3 Boiling Point 333.8±32.0 °C at 760 mmHg
Molecular Formula C5H4D5NO4 Melting Point 205ºC (dec.)(lit.)
MSDS N/A Flash Point 155.7±25.1 °C

 Use of L-Glutamic acid-d5


L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.

 Names

Name (2S)-2-amino-2,3,3,4,4-pentadeuteriopentanedioic acid
Synonym More Synonyms

 L-Glutamic acid-d5 Biological Activity

Description L-Glutamic acid-d5 is the deuterium labeled L-Glutamic acid. L-Glutamic acid acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). L-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 333.8±32.0 °C at 760 mmHg
Melting Point 205ºC (dec.)(lit.)
Molecular Formula C5H4D5NO4
Molecular Weight 152.160
Flash Point 155.7±25.1 °C
Exact Mass 152.084549
PSA 100.62000
LogP -1.43
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.522
Storage condition -20°C

 Safety Information

WGK Germany 3

 Synonyms

L-(2,3,3,4,4-H)Glutamic acid
glutamic acid-d5
2,3,3,4,4-pentadeuterio-L-glutamic acid
Glusate-d5
L-Glutamic-2,3,3,4,4-d acid
L-glutamic-2,3,3,4,4-d5 acid
Glutacid-d5
Glutamicol-d5
L-|A-Aminoglutaric Acid-d5
Glutaminol-d5
Glutaton-d5
Glutamidex-d5
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