TH-Z835

Modify Date: 2025-08-26 10:45:53

TH-Z835 Structure
TH-Z835 structure
 Common Name TH-Z835
CAS Number 2766209-50-9 Molecular Weight 498.66
Density N/A Boiling Point N/A
Molecular Formula C30H38N6O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TH-Z835


TH-Z835 is a mutant selective KRAS (G12D) inhibitor with an IC50 of 1.6 μM. TH-Z835 inhibits both mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange[1].

 Names

Name TH-Z835

 TH-Z835 Biological Activity

Description TH-Z835 is a mutant selective KRAS (G12D) inhibitor with an IC50 of 1.6 μM. TH-Z835 inhibits both mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange[1].
Related Catalog
Target

KRAS(G12D):1.6 μM (IC50)

References

[1]. Mao Z, et al. KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8(1):5.  

 Chemical & Physical Properties

Molecular Formula C30H38N6O
Molecular Weight 498.66
InChIKey KIWVGCSJQTTZJO-VHYCJAOWSA-N
SMILES Cc1cccc2cccc(N3CCc4c(nc(OCC5CCCN5C)nc4N4CC5CCC(C4)N5)C3)c12
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Chemsrc provides TH-Z835(CAS#:2766209-50-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of TH-Z835 are included as well.>> amp version: TH-Z835

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