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2766209-50-9

2766209-50-9 structure

2766209-50-9 structure

Name: TH-Z835
Chemical Name: TH-Z835
CAS Number: 2766209-50-9
Molecular Formula: C₃₀H₃₈N₆O
Molecular Weight: 498.66
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-10-23 02:22:29
Modify Date: 2025-08-26 10:45:53
TH-Z835 is a mutant selective KRAS (G12D) inhibitor with an IC50 of 1.6 μM. TH-Z835 inhibits both mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange[1].

Name	TH-Z835

Description	TH-Z835 is a mutant selective KRAS (G12D) inhibitor with an IC50 of 1.6 μM. TH-Z835 inhibits both mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRAS(G12D):1.6 μM (IC50)
References	[1]. Mao Z, et al. KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8(1):5.

Molecular Formula	C₃₀H₃₈N₆O
Molecular Weight	498.66

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