TH-Z835

Names

[ CAS No. ]:
2766209-50-9

[ Name ]:
TH-Z835

Biological Activity

[Description]:

TH-Z835 is a mutant selective KRAS (G12D) inhibitor with an IC50 of 1.6 μM. TH-Z835 inhibits both mantGMPPNP/GPPNP exchange and GPPNP/mantGMPPNP exchange[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> GPCR/G Protein >> Ras

[Target]

KRAS(G12D):1.6 μM (IC50)


[References]

[1]. Mao Z, et al. KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8(1):5.  

Chemical & Physical Properties

[ Molecular Formula ]:
C30H38N6O

[ Molecular Weight ]:
498.66

Related Compounds

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