STL5-T-0057

Modify Date: 2025-08-28 00:01:32

STL5-T-0057 Structure
STL5-T-0057 structure
Common Name STL5-T-0057
CAS Number 2756014-24-9 Molecular Weight 445.94
Density N/A Boiling Point N/A
Molecular Formula C26H24ClN3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of STL5-T-0057


STL5-T-0057 (compound 68) is an selective ALDH1 B1 inhibitor with an IC50 value of 30 nM. STL5-T-0057 inhibits cell growth of SW480 cells in adherent and spheroid conditions with IC50 values of 2.46 and 0.39 μM, respectively. STL5-T-0057 can be used for the research of cancer[1].

 Names

Name STL5-T-0057

 STL5-T-0057 Biological Activity

Description STL5-T-0057 (compound 68) is an selective ALDH1 B1 inhibitor with an IC50 value of 30 nM. STL5-T-0057 inhibits cell growth of SW480 cells in adherent and spheroid conditions with IC50 values of 2.46 and 0.39 μM, respectively. STL5-T-0057 can be used for the research of cancer[1].
Related Catalog
Target

IC50: 30 nM (ALDH1 B1), 2.46 μM (SW480, adherent), 0.39 μM (SW480, spheroid)[1]

In Vitro STL5-T-0057 (0-10 μM) inhibits ALDH1 B1 with an IC50 value of 30 nM[1]. STL5-T-0057 (0.01-10 μM; 4-5 d) inhibits cell growth of HEK293T cells[1]. STL5-T-0057 (0.01-10 μM) inhibits cell viability of SW480 cells in adherent and spheroid conditions with IC50 values of 2.46 and 0.39 μM, respectively[1]. Cell Cytotoxicity Assay[1] Cell Line: HEK293T cell line Concentration: 0.01-10 μM Incubation Time: 4-5 d Result: Showed cell cytotoxicity to HEK293T cells with a GI50 value of 1.7 μM.
References

[1]. Chen Jame Kenneth, et al. Preparation of substituted imidazolium or cyclic guanidine compounds as isoform-specific aldehyde dehydrogenase inhibitors for the treatment of cancer. WO2021257696 A1. 2021.

 Chemical & Physical Properties

Molecular Formula C26H24ClN3O2
Molecular Weight 445.94
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