STL5-T-0057

STL5-T-0057 (compound 68) is an selective ALDH1 B1 inhibitor with an IC50 value of 30 nM. STL5-T-0057 inhibits cell growth of SW480 cells in adherent and spheroid conditions with IC50 values of 2.46 and 0.39 μM, respectively. STL5-T-0057 can be used for the research of cancer[1].

Signaling Pathways >> Metabolic Enzyme/Protease >> Aldehyde Dehydrogenase (ALDH)

Research Areas >> Cancer

IC50: 30 nM (ALDH1 B1), 2.46 μM (SW480, adherent), 0.39 μM (SW480, spheroid)[1]

STL5-T-0057 (0-10 μM) inhibits ALDH1 B1 with an IC50 value of 30 nM[1]. STL5-T-0057 (0.01-10 μM; 4-5 d) inhibits cell growth of HEK293T cells[1]. STL5-T-0057 (0.01-10 μM) inhibits cell viability of SW480 cells in adherent and spheroid conditions with IC50 values of 2.46 and 0.39 μM, respectively[1]. Cell Cytotoxicity Assay[1] Cell Line: HEK293T cell line Concentration: 0.01-10 μM Incubation Time: 4-5 d Result: Showed cell cytotoxicity to HEK293T cells with a GI50 value of 1.7 μM.

[1]. Chen Jame Kenneth, et al. Preparation of substituted imidazolium or cyclic guanidine compounds as isoform-specific aldehyde dehydrogenase inhibitors for the treatment of cancer. WO2021257696 A1. 2021.