HIV-1 inhibitor-57

Modify Date: 2024-02-18 11:29:45

HIV-1 inhibitor-57 Structure
HIV-1 inhibitor-57 structure
Common Name HIV-1 inhibitor-57
CAS Number 2745197-24-2 Molecular Weight 493.55
Density N/A Boiling Point N/A
Molecular Formula C25H24FN5O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HIV-1 inhibitor-57


HIV-1 inhibitor-57 (Compound 12g) is a HIV inhibitor. HIV-1 inhibitor-57 is active against wild-type and five prevalent NNRTI-resistant HIV-1 strains with EC50 values ranging from 0.024 to 0.0010 μM. HIV-1 inhibitor-57 forms additional interactions with residues around the binding site in HIV-1 RT[1].

 Names

Name HIV-1 inhibitor-57

 HIV-1 inhibitor-57 Biological Activity

Description HIV-1 inhibitor-57 (Compound 12g) is a HIV inhibitor. HIV-1 inhibitor-57 is active against wild-type and five prevalent NNRTI-resistant HIV-1 strains with EC50 values ranging from 0.024 to 0.0010 μM. HIV-1 inhibitor-57 forms additional interactions with residues around the binding site in HIV-1 RT[1].
Related Catalog
References

[1]. Jiang X, et al. Discovery of novel diarypyrimidine derivatives bearing six-membered non-aromatic heterocycles as potent HIV-1 NNRTIs with improved anti-resistance and drug-like profiles. Eur J Med Chem. 2023 Oct 5;258:115605.  

 Chemical & Physical Properties

Molecular Formula C25H24FN5O3S
Molecular Weight 493.55
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