HIV-1 inhibitor-57

Names

[ CAS No. ]:
2745197-24-2

[ Name ]:
HIV-1 inhibitor-57

Biological Activity

[Description]:

HIV-1 inhibitor-57 (Compound 12g) is a HIV inhibitor. HIV-1 inhibitor-57 is active against wild-type and five prevalent NNRTI-resistant HIV-1 strains with EC50 values ranging from 0.024 to 0.0010 μM. HIV-1 inhibitor-57 forms additional interactions with residues around the binding site in HIV-1 RT[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[References]

[1]. Jiang X, et al. Discovery of novel diarypyrimidine derivatives bearing six-membered non-aromatic heterocycles as potent HIV-1 NNRTIs with improved anti-resistance and drug-like profiles. Eur J Med Chem. 2023 Oct 5;258:115605.  

Chemical & Physical Properties

[ Molecular Formula ]:
C25H24FN5O3S

[ Molecular Weight ]:
493.55

Related Compounds

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