SRI-42127
Modify Date: 2025-11-24 17:48:56
SRI-42127 structure
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Common Name | SRI-42127 | ||
|---|---|---|---|---|
| CAS Number | 2727872-68-4 | Molecular Weight | 348.40 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H20N6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SRI-42127SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes[1]. |
| Name | SRI-42127 |
|---|
| Description | SRI-42127 is a HuR translocation inhibitor. HuR is an RNA regulator that binds to AREs, and HuR translocations promote the production of inflammatory cytokines in glial cells. However, SRI-42127 can destroy mRNA stability and inhibit gene promoter activation. SRI-42127 also inhibits microglial cell activation and attenuates recruitment/chemotaxis of neutrophils and monocytes[1]. |
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| Related Catalog | |
| Target |
HuR[1] |
| In Vitro | SRI-42127 (0.05-1 μM; 24 h) 阻断 LPS (1 μg/mL) 刺激原代小胶质细胞的 HuR 细胞质转位[1]。 SRI-42127 (0.05-1 μM; 24 h) 抑制激活的原代小胶质细胞 (PMG) 中炎症细胞因子和趋化因子 mRNA 水平[1]。 SRI-42127 (0.5 μM 和 1 μM; 24 h) 阻断胶质细胞产生的中性粒细胞和单核细胞的化学吸引/迁移信号[1]。 |
| In Vivo | SRI-42127 (15 mg/kg; 腹腔注射; 单剂量) 抑制小鼠模型中 HuR 易位和小胶质细胞活化[1]。 |
| References |
| Molecular Formula | C19H20N6O |
|---|---|
| Molecular Weight | 348.40 |
| InChIKey | AEHZEVSNZUVPNR-UHFFFAOYSA-N |
| SMILES | CN(c1ccc2ncc(-c3ccc4cn[nH]c4c3)n2n1)C1CCOCC1 |