JAK-IN-27

Modify Date: 2025-09-07 12:46:28

JAK-IN-27 structure	Common Name	JAK-IN-27
	CAS Number	2673176-36-6	Molecular Weight	413.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₁F₂N₇O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JAK-IN-27

JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM)[1].

Name	JAK-IN-27

Description	JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK
Target	IC50: 3.0 nM (TYK2)、7.7 nM (JAK1)、629.6 nM (JAK3)
References	[1]. Zhang P, et al. Preparation of pyrazolo[1,5-a]pyrazine derivatives and its use as JAK family kinase inhibitors. China, CN113150012 A. 2021-07-23.

Molecular Formula	C₂₀H₂₁F₂N₇O
Molecular Weight	413.42
InChIKey	QYCVEBICDFQYBS-NRXISQOPSA-N
SMILES	Cn1cc(-c2cn3nccc3c(N3CC4CCC(C3)N4C(=O)C3CC3(F)F)n2)cn1

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JAK-IN-27

Use of JAK-IN-27

Names

JAK-IN-27 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.