2673176-36-6

2673176-36-6 structure

Name: JAK-IN-27
Chemical Name: JAK-IN-27
CAS Number: 2673176-36-6
Molecular Formula: C₂₀H₂₁F₂N₇O
Molecular Weight: 413.42
Catalog: Signaling Pathways Epigenetics JAK
Create Date: 2023-09-18 18:10:12
Modify Date: 2024-01-10 12:07:36
JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM)[1].

Name	JAK-IN-27

Description	JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK
Target	IC50: 3.0 nM (TYK2)、7.7 nM (JAK1)、629.6 nM (JAK3)
References	[1]. Zhang P, et al. Preparation of pyrazolo[1,5-a]pyrazine derivatives and its use as JAK family kinase inhibitors. China, CN113150012 A. 2021-07-23.

Molecular Formula	C₂₀H₂₁F₂N₇O
Molecular Weight	413.42