JAK-IN-27

Names

[ CAS No. ]:
2673176-36-6

[ Name ]:
JAK-IN-27

Biological Activity

[Description]:

JAK-IN-27 (compound 1) is an orally active and potent JAKS family kinase inhibitor with IC50s of 3.0 nM (TYK2), 7.7 nM (JAK1), 629.6 nM (JAK3), respectively. JAK-IN-27 inhibits IFN-α2B-induced phosphorylation of STAT3 in Jurkat cells (IC50=23.7 nM)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK

[Target]

IC50: 3.0 nM (TYK2)、7.7 nM (JAK1)、629.6 nM (JAK3)


[References]

[1]. Zhang P, et al. Preparation of pyrazolo[1,5-a]pyrazine derivatives and its use as JAK family kinase inhibitors. China, CN113150012 A. 2021-07-23.

Chemical & Physical Properties

[ Molecular Formula ]:
C20H21F2N7O

[ Molecular Weight ]:
413.42

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.