JPS016
Modify Date: 2025-08-27 08:30:48
JPS016 structure
|
Common Name | JPS016 | ||
|---|---|---|---|---|
| CAS Number | 2669785-77-5 | Molecular Weight | 898.12 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C48H63N7O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JPS016JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS016 degrades class I histone deacetylase (HDAC). JPS016 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1]. |
| Name | JPS016 |
|---|
| Description | JPS016 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS016 degrades class I histone deacetylase (HDAC). JPS016 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1]. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C48H63N7O8S |
|---|---|
| Molecular Weight | 898.12 |
| InChIKey | BOXZMOCGSKLDAH-OUZJXKGJSA-N |
| SMILES | Cc1ncsc1-c1ccc(CNC(=O)C2CC(O)CN2C(=O)C(NC(=O)COCCCCCCCCCOCC(=O)Nc2ccc(C(=O)Nc3ccccc3N)cc2)C(C)(C)C)cc1 |