BChE-IN-8

Modify Date: 2025-11-26 11:48:17

BChE-IN-8 Structure
BChE-IN-8 structure
 Common Name BChE-IN-8
CAS Number 2653349-78-9 Molecular Weight 438.24
Density N/A Boiling Point N/A
Molecular Formula C18H12BrN7O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BChE-IN-8


BChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.15 nM (eqBChE, equine serum BChE) and 45.2 nM (hBChE), respectively. High stability of BChE-IN-8 contributes to significantly improved blood concentration and tissue exposure. BChE-IN-8 can exert neuro-protecting and cognition improving properties through multiple modulations, including cholinergic system, Aβ aggregation, neuropeptide levels. BChE-IN-8 can be used for Alzheimer's disease (AD) research[1].

 Names

Name BChE-IN-8

 BChE-IN-8 Biological Activity

Description BChE-IN-8 (compound 20) is an orally active, potent and BBB-penetrated BChE (butyrylcholinesterase) inhibitor, with IC50 values of 0.15 nM (eqBChE, equine serum BChE) and 45.2 nM (hBChE), respectively. High stability of BChE-IN-8 contributes to significantly improved blood concentration and tissue exposure. BChE-IN-8 can exert neuro-protecting and cognition improving properties through multiple modulations, including cholinergic system, Aβ aggregation, neuropeptide levels. BChE-IN-8 can be used for Alzheimer's disease (AD) research[1].
Related Catalog
Target

IC50: 0.15 ± 0.10 nM (eqBChE), 45.2 ± 45.0 nM (hBChE) [1]

References

[1]. Li Q, Xiong B, Wang Y, Lyu W, Xing S, Chen Y, Liao Q, He S, Feng F, Liu W, Chen Y, Sun H. A highly effective and stable butyrylcholinesterase inhibitor with multi-faceted neuroprotection and cognition improvement. Eur J Med Chem. 2022 Jun 7;239:114510.

 Chemical & Physical Properties

Molecular Formula C18H12BrN7O2
Molecular Weight 438.24
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Chemsrc provides BChE-IN-8(CAS#:2653349-78-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of BChE-IN-8 are included as well.>> amp version: BChE-IN-8

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