2304818-41-3
2304818-41-3 structure
- Name: BChE-IN-4
- Chemical Name: BChE-IN-4
- CAS Number: 2304818-41-3
- Molecular Formula: C24H37N3O
- Molecular Weight: 383.57
- Catalog: Signaling Pathways Neuronal Signaling AChE
- Create Date: 2022-07-11 21:20:13
- Modify Date: 2024-01-10 18:41:09
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BChE-IN-4 is a potent and cross the blood-brain barrier BChE inhibitor. BChE-IN-4 attenuates learning and memory deficits caused by cholinergic deficit in mouse model. BChE-IN-4 has the potential for the research of alzheimer’s disease[1].
| Name | BChE-IN-4 |
|---|
| Description | BChE-IN-4 is a potent and cross the blood-brain barrier BChE inhibitor. BChE-IN-4 attenuates learning and memory deficits caused by cholinergic deficit in mouse model. BChE-IN-4 has the potential for the research of alzheimer’s disease[1]. |
|---|---|
| Related Catalog | |
| Target |
BChE[1] |
| In Vivo | BChE-IN-4 (compound 1) (10, 20, 30 mg/kg) attenuates learning and memory deficits caused by cholinergic deficit in AD mouse model[1]. BChE-IN-4 (30 mg/kg) dose not induce adverse motor effects in vivo[1]. Animal Model: Adult male Albino Swiss CD-1 mice (Scopolamine-induced memory-impaired CD-1 mice)[1] Dosage: 10, 20, 30 mg/kg Administration: I.p. Result: Significantly prolonged the step-through latencies in memory impaired mice. Animal Model: 18-22 g, C57BL/6J mice[1] Dosage: 30 mg/kg Administration: I.p. Result: Did not enhance learning abilities and working memory in the acquisition phase or the short-term memory retrieval on day 5, but did significantly improve long-term memory retrieval, as observed on day 12 of the BM ( Barnes maze) task. Animal Model: Mice[1] Dosage: 30 mg/kg (suspended in 1% Tween 80) Administration: I.p Result: Neither altered the number of light-beam interruptions in the locomotor activity test nor induced any motor deficits at 6, 18 and 24 rpm in the rotarod test. |
| References |
| Molecular Formula | C24H37N3O |
|---|---|
| Molecular Weight | 383.57 |