Zanapezil
Modify Date: 2024-01-10 19:25:24
Zanapezil structure
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Common Name | Zanapezil | ||
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| CAS Number | 263248-42-6 | Molecular Weight | 492.60700 | |
| Density | N/A | Boiling Point | 547ºC at 760mmHg | |
| Molecular Formula | C29H36N2O5.xC4H4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 284.6ºC | |
Use of ZanapezilZanapezil (TAK-147) fumarate is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil fumarate shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil fumarate shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil fumarate can be used for the research of early stages of Alzheimer's disease (AD)[1][2]. |
| Name | 3-(1-Benzyl-4-piperidinyl)-1-(2,3,4,5-tetrahydro-1H-1-benzazepin- 8-yl)-1-propanone (2E)-2-butenedioate (1:1) |
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| Description | Zanapezil (TAK-147) fumarate is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil fumarate shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil fumarate shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil fumarate can be used for the research of early stages of Alzheimer's disease (AD)[1][2]. |
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| Related Catalog | |
| Target |
AChE |
| References |
| Boiling Point | 547ºC at 760mmHg |
|---|---|
| Molecular Formula | C29H36N2O5.xC4H4O4 |
| Molecular Weight | 492.60700 |
| Flash Point | 284.6ºC |
| Exact Mass | 492.26200 |
| PSA | 106.94000 |
| LogP | 5.09760 |