MRTX9768
Modify Date: 2025-08-25 10:09:51
MRTX9768 structure
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Common Name | MRTX9768 | ||
|---|---|---|---|---|
| CAS Number | 2629314-68-5 | Molecular Weight | 424.43 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H17FN6O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MRTX9768MRTX9768 is a potent, orally active PRMT5 inhibitor. MRTX9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors[1]. |
| Name | MRTX9768 |
|---|
| Description | MRTX9768 is a potent, orally active PRMT5 inhibitor. MRTX9768 is a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors[1]. |
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| Related Catalog | |
| Target |
PRMT5[1] |
| In Vitro | MRTX9768 inhibits SDMA and cell proliferation in HCT116 MTAP-del cells (SDMA IC50 3 nM; prolif. IC50 11 nM) with marked selectivity over HCT116 MTAP-WT cells (SDMA IC50 544 nM; prolif. IC50 861 nM)[1]. |
| In Vivo | In xenograft studies, oral administration of MRTX9768 demonstrates dose-dependent inhibition of SDMA in MTAP-del tumors[1]. |
| References |
| Molecular Formula | C24H17FN6O |
|---|---|
| Molecular Weight | 424.43 |
| InChIKey | BPTYWAYMKBEXES-UHFFFAOYSA-N |
| SMILES | Cn1ncc(-c2ccc3c(=O)[nH]nc(CN)c3c2)c1-c1c(F)cc2ccccc2c1C#N |